Past Contract Topics
To learn more about the components of the NCI SBIR Contract Solicitation and the kinds of projects NIH is helping to advance, you can explore past contract solicitations on this page.
Previous years' contract solicitations
PHS 2024 included 11 contract topics released by NCI:
- 455 - Point-of-Care Detection of Prostate-Specific Antigen
- 456 - Rapid and Affordable Point-of-Care HPV Diagnostics for Cervical Cancer Control
- 457 - Technologies for Detecting Tumor-Derived Cell Clusters
- 458 - Microbiome-Based Tests for Cancer Research, Diagnosis, Prognosis and/or Patient Management
- 459 - Automated Software for Point-of-Care Testing to Identify Cancer-Associated Malnutrition
- 460 - Evaluation Datasets as Medical Device Development Tools for Testing Cancer Technologies
- 461 - Ultra-Fast Dose Rate (FLASH) Radiation Detectors and Safety Systems for Cancer Treatment
- 462 - Organ-on-Chip for Preclinical and Translational Radiobiological Studies
- 463 - Translation of Novel Cancer-specific Imaging Agents and Techniques to Mediate Successful Image-guided Cancer Interventions
- 464 - Cloud-Based Multimodal Data Analysis Software for the Cancer Research Data Commons
- 465 - Prevention and Treatment Clinical Trials Tools for Recruitment and Retention of Diverse Populations
PHS 2023 included 9 contract topics released by NCI:
- 446 - Development of Senotherapeutic Agents for Cancer Treatment
- 447 - Non-invasive Device Technology Research & Development for Chemotherapy-induced Peripheral Neuropathy Management
- 448 - Wearable Devices for Dosimetry of Radiopharmaceutical Therapy
- 449 - Wearable Technologies to Facilitate Remote Monitoring of Cancer Patients Following Treatment
- 450 - Technology Platforms for Circulating Tumor-Macrophage Hybrid Cells
- 451 - Rapid and Affordable Point-of-Care HPV Diagnostics for Cervical Cancer Control
- 452 - Translation of Novel Cancer-Specific Imaging Agents and Techniques to Mediate Successful Image-Guided Cancer Interventions
- 453 - Digital Tools to Integrate Cancer Prevention Within Primary Care
- 454 - Software to Evaluate Artificial Intelligence/Machine Learning Medical Devices in Oncology Settings
PHS 2022 included 16 contract topics released by NCI:
- 430 - Development of Senotherapeutic Agents for Cancer Treatment
- 431 - Cancer Treatment Technologies for Low-resource Settings
- 432 - Synthetic Biology Gene Circuits for Cancer Therapy
- 433 - Developing Unbiased Medical Technologies to Reduce Disparities in Cancer Outcomes
- 434 - Ultra-fast Dose Rate (FLASH) Radiation Detectors and Safety Systems
- 435 - Devices to Treat Secondary Lymphedema Following Cancer Treatment
- 436 - New Technologies to Analyze Extra-chromosomal DNA in Cancer
- 437 - 3D Spatial Omics for Molecular and Cellular Tumor Atlas Construction
- 438 - Understanding Cancer Tumor Genomic Results: Technology Applications for Community Providers
- 439 - Advanced Sample Processing Platforms for Downstream Single-cell Multi-omic Analysis
- 440 - Cancer Prevention and Diagnosis Technologies for Low-resource Settings
- 441 - At-home Screening for Hepatitis C Virus
- 442 - Quantitative Biomarkers as Medical Device Development Tools for Cancer
- 443 - Development of Computer-aided Diagnosis Tools for Upper and Lower Gastrointestinal Tract Cancer Prevention
- 444 - Evaluation Datasets as Medical Device Development Tools for Testing Cancer Technologies
- 445 - Advanced Manufacturing to Speed Availability of Emerging Autologous Cell-based Therapies
PHS 2021 included 17 contract topics released by NCI:
- 413 - Next Generation 3D Tissue Culture Systems with Tertiary Lymphoid Organs
- 414 - Synthetic Biology Gene Circuits for Cancer Therapy
- 415 - Applicator-Compatible Electronic Brachytherapy Sources for Cancer Radiotherapy
- 416 - Self-Sampling Devices for HPV-Testing-Based Cervical Cancer Screening
- 417 - Quantitative Imaging Software Tools for Cancer Diagnosis and Treatment Planning
- 418 - 3D Spatial Omics for Molecular and Cellular Tumor Atlas Construction
- 419 - Understanding Cancer Tumor Genomic Results: Technology Applications for Providers
- 420 - Single-Cell “Unbiased Discovery” Proteomic Technologies
- 421 - Quantitative Biomimetic Phantoms for Cancer Imaging and Radiation Dosimetry
- 422 - Spatial Sequencing Technologies with Single Cell Resolution for Cancer Research and Precision Medicine
- 423 - Software to Address Social Determinants of Health in Oncology Practices
- 424 - Digital Tools to Improve Health Outcomes in Pediatric Cancer Survivors
- 425 - Information Technology Tools for Automated Analysis of Physical Activity, Performance, and Behavior from Images for Improved Cancer Health
- 426 - Tools and Technologies for Visualizing Multi-Scale Data
- 427 - De-Identification Software Tools and Pipelines for Cancer Imaging Research
- 428 - Cloud-Based Multi-Omic and Imaging Software for the Cancer Research Data Commons
- 429 - Advanced Manufacturing to Speed Availability of Emerging Autologous Cell-Based Therapies
PHS 2020 included 16 contract topics released by NCI:
- 397 - Manufacturing Innovation for the Production of Cell-Based Cancer Immunotherapies
- 398 - Development of Senolytic Agents for Cancer Treatment
- 399 - Combinatory Treatment Utilizing Radiation to Locally Activate Systemically Delivered Therapeutics
- 400 - Sensing Tools to Measure Biological Response to Radiotherapy
- 401 - Quantitative Biomimetic Phantoms for Cancer Imaging
- 402 - Artificial Intelligence-Aided Imaging for Cancer Prevention, Diagnosis, and Monitoring
- 403 - Spatial Sequencing Technologies with Single Cell Resolution for Cancer Research
- 404 - Subcellular Microscopy and -Omics in Cancer Cell Biology
- 405 - Intra-Tumor Sensing Technologies for Tumor Pharmacotyping
- 406 - Software for Patient Navigation Through the Cancer Care Continuum
- 407 - Cloud-Based Software for the Cancer Research Data Commons
- 408 - Tools and Technologies for Visualizing Multi-Scale Data
- 409 - Software for Automated Analysis of Images for Improved Cancer Health
- 410 - Cancer Clinical Trials Recruitment and Retention Tools for Participant Engagement
- 411 - De-Identification Software Tools for Cancer Imaging Research
- 412 - Software Enabling Data Integration from Wearable Sensors for Cancer Patients
PHS 2019 included 15 contract topics released by NCI:
- 382 - Integrated Subcellular Microscopy and ‘Omics in Cancer Cell Biology
- 383 - Smart, Multi-Core Biopsy Needle
- 384 - Digital Healthcare Platform to Reduce Financial Hardship for Cancer Patients
- 385 - Leveraging Connected Health Technologies to Address and Improve Health Outcomes of Long-Term Cancer Survivors
- 386 - Novel Approaches for Local Delivery of Chemopreventive Agents
- 387 - Multiplexed Preclinical Tools for Longitudinal Characterization of Immunological Status in Tumor and its Microenvironment
- 388 - In vitro Diagnostic for the Liver Flukes Opisthorchis viverrini and Clonorchis sinensis
- 389 - Development of Artificial Intelligence (AI) Tools to Understand and Duplicate Experts' Radiation Therapy Planning for Prostate Cancer
- 390 - Clonogenic High-Throughput Assay for Screening Anti-Cancer Agents and Radiation Modulators
- 391 - Drugs or Devices to Exploit the Immune Response Generated by Radiation Therapy
- 392 - Clinical Trials of Systemic Targeted Radionuclide Therapies
- 393 - Sensing Tools to Measure Biological Response to Radiotherapy
- 394 - Combinatory Treatment Modalities Utilizing Radiation to Locally Activate or Release Systemically Delivered Therapeutics
- 395 - Targeted Therapy for Cancer- and Cancer Therapy-Related Cachexia
- 396 - Imaging for Cancer Immunotherapies
PHS 2018 included 12 contract topics released by NCI:
- 370 - Targeted Therapy for Cancer- and Cancer Therapy-Related Cachexia
- 371 - Drugs to Exploit the Immune Response Generated by Radiation Therapy
- 372 - Development and Validation of Non-Mouse Reagents to Enable Preclinical Development of Novel Therapeutics
- 373 - Tools and Technologies for Monitoring RNA Modifications
- 374 - Novel Approaches for Local Delivery of Chemopreventive Agents
- 375 - Diagnostic Imaging for Cancer Immunotherapies
- 376 - Imaging-Based Tools for Longitudinal and Multi-Dimensional Mapping of the Tumor and its Microenvironment
- 377 - Bridging the Guideline Implementation Gap: Clinical Decision-Support to Improve Cancer Symptom Management
- 378 - Mobile Application for Surveillance of Post-Radiation Therapy Health-Related Quality of Life
- 379 - Software Enabling Data Integration from Wearable Sensors to Generate Novel Analytics for Cancer Patients
- 380 - Computer Aided Decision Support for Radiation Oncology
- 381 - Development of Artificial Intelligence (AI) Tools to Understand and Duplicate Experts’ Radiation Therapy Planning for Prostate Cancer