Current NCI SBIR Contract Solicitation
Program Solicitation PHS 2025-1
The pre-solicitation is now available [View pre-solicitation].
FY25 solicitation release anticipated summer 2024.
The FY25 SBIR Contract Solicitation topic names are now available. See below for the 13 topics that will be included in this year's solicitation.
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NIH/NCI 466 - Novel Delivery Systems for RNA-based Cancer Vaccines
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NIH/NCI 467 - Development of Cancer Immunoprevention Agents
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NIH/NCI 468 - Synthetic Microbes (Excluding Oncolytic Viruses) for Immuno-Oncology Therapies
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NIH/NCI 469 - Development of Novel Therapeutics for HPV-related Precancer
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NIH/NCI 470 - Precision Nutrition Interventions to Reduce Cancer-Related Symptoms
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NIH/NCI 471 - Drug-Loaded Carrier Particles for Improved Oral Delivery for Colon Cancer Prevention
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NIH/NCI 472 - Antibody-Drug Conjugates as Radiopharmaceutical Theranostics for Cancer
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NIH/NCI 473 - Point of Care Detection of Antibodies Against HPV16/18 E6 and E7 Oncoproteins in Oropharyngeal Cancer
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NIH/NCI 474 - Point of Care Technologies for GI Cancer Prevention and Early Detection
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NIH/NCI 475 - Development of Digital Biomarkers and Endpoints for Clinical Cancer Care
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NIH/NCI 476 - Digital Twin Software for Optimization of Cancer Radiation Therapy
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NIH/NCI 477 - Wearable Technologies to Facilitate Remote Monitoring of Cancer Patients Following Treatment
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NIH/NCI 478 - Advanced Biomaterials to Improve Cancer Modeling for Research
For additional information, please see the NCI Board of Scientific Advisors (BSA) presentation on the FY25 SBIR Contract Solicitation topics.
Applicants must use the Contract Proposal Submission (eCPS) website to submit their proposal. No other method of proposal submission is permitted. Instructions for electronic submission are provided in the solicitation. Actual contract topic numbers will be available in the solicitation.
For more information, contact Cherie Wells, contract analyst in the Office of Acquisitions, at ncioasbir@mail.nih.gov.
For reference, see below for the 11 topics that were included in last year's FY24 SBIR Contract solicitation.
- NIH/NCI 455 - Point-of-Care Detection of Prostate-Specific Antigen
- NIH/NCI 456 - Rapid and Affordable Point-of-Care HPV Diagnostics for Cervical Cancer Control
- NIH/NCI 457 - Technologies for Detecting Tumor-Derived Cell Clusters
- NIH/NCI 458 - Microbiome-Based Tests for Cancer Research, Diagnosis, Prognosis and/or Patient Management
- NIH/NCI 459 - Automated Software for Point-of-Care Testing to Identify Cancer-Associated Malnutrition
- NIH/NCI 460 - Evaluation Datasets as Medical Device Development Tools for Testing Cancer Technologies
- NIH/NCI 461 - Ultra-Fast Dose Rate (FLASH) Radiation Detectors and Safety Systems for Cancer Treatment
- NIH/NCI 462 - Organ-on-Chip for Preclinical and Translational Radiobiological Studies
- NIH/NCI 463 - Translation of Novel Cancer-specific Imaging Agents and Techniques to Mediate Successful Image-guided Cancer Interventions
- NIH/NCI 464 - Cloud-Based Multimodal Data Analysis Software for the Cancer Research Data Commons
- NIH/NCI 465 - Prevention and Treatment Clinical Trials Tools for Recruitment and Retention of Diverse Populations