Skip to main content

Small Business Application Process and Resources

This page features resources to help small businesses apply for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) funding.

SBIR/STTR Application Basics

Who is Eligible for SBIR/STTR Funding?

The NCI's SBIR/STTR funding is for small businesses based in the United States. Companies must meet eligibility criteria.

  • Status: Applicant must be a for-profit US small business.
  • Location: Applicant must be based in the US, with work performed in the US.
  • Size: Applicant must have 500 or fewer employees, including affiliates.
  • Ownership: >50% owned by U.S. individuals and independently operated OR
    • >50% owned and controlled by another (one) business concern that is >50% owned and controlled by one or more individuals OR 
    • >50% owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these (SBIR only)

SBIR/STTR Sample Applications

  • Penelope Duerksen-Hughes, Ph.D., of ISPIN, Inc., "A novel combinatorial approach for treating HPV-associated malignancies"
  • Alexander Krupnick, M.D., of Courier Therapeutics, Inc., "Novel Immuno-oncology Strategy for Targeted Cytotoxic Lymphocyte Activation"

NIH Funding Processes

  • NIH SBIR/STTR Application Processes—Learn about the National Institutes of Health (NIH) SBIR/STTR funding application processes.
  • NIH Grant Processes—Learn about the steps required for an application to proceed from planning and submission through to award and closeout.
  • NIH SBIR/STTR Just-in-Time Procedures—The Just-in-Time feature of the eRA Commons allows a signing official to electronically submit additional grant application information that is requested by the grantor agency after the completion of the peer review and prior to funding.
  • NIH ASSIST—The Application Submission System & Interface for Submission Tracking (ASSIST) system is used to prepare and submit grant applications electronically to NIH.

NIH Resources

  • NCI Resources for Researchers—Find NCI-supported tools and services for cancer researchers.
  • NIH Matchmaker—Use this site to conduct keyword searches on particular topic areas to identify NIH Institutes and Centers that have previously funded research in that area.
  • NIH RePORTER—Find previously funded projects through this site.

Non-NIH Resources

  • Updated:

If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Small Business Application Process and Resources was originally published by the National Cancer Institute.”