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Notice of Special Interest (NOSI): Women’s Health Research

Notice of Special Interest: NOT-OD-24-079

First Available Due Date: May 06, 2024

Expires on: November 05, 2027

 

In alignment with the White House Initiative on Women’s Health Research, the National Institutes of Health (NIH) is issuing this Notice of Special Interest to highlight interest in receiving research applications focused on diseases and health conditions that predominantly affect women (e.g., autoimmune diseases; depressive disorders, Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD), gender-based-violence), present and progress differently in women (e.g., cardiovascular disease; HIV; reproductive aging and its implications), or are female-specific (e.g., uterine fibroids; endometriosis; menopause).

For consideration under this NOSI, applications must have a central focus on the health of women, as demonstrated through specific aims that EITHER explicitly address a particular condition in women OR focus on one of the high-priority topics below. 

High-priority topics across NIH include but are not limited to:

  • Projects that investigate the influence of sex-linked biology, gender-related factors, or their intersections on health.
  • Projects that investigate how physical, mental, and psychological health outcomes interact with structural factors to either mitigate or exacerbate health disparities, and aim to create behavioral interventions to address these issues.
  • Projects that advance the translation of research advancements and evidence in women’s health into practical benefits for patients and providers
  • Projects to inform and develop multi-sector partnerships to advance innovation in women's health research
  • Research to increase public awareness of the need for greater investment in and attention to women’s health research, as well as women’s health outcomes across the lifespan
  • Projects that advance research to reduce health disparities and inequities affecting women’s health, including those related to race, ethnicity, age, socioeconomic status, disability, and exposure to environmental factors and contaminants that can directly affect health
  • Dissemination and implementation research to increase uptake of evidence-based interventions that advance women’s health
  • Projects addressing topics identified in the Women’s Health Innovation Opportunity Map.

 

Application and Submission Information

Applicants must submit applications for this initiative using one of the notices of funding opportunity (NOFOs) or any reissues of these announcements listed in this NOSI through its expiration date.

Applicants must select the Institutes and Centers (ICs) and associated NOFO to use for submission of an application in response to this NOSI. Applications must be aligned with one of the mission areas of the selected IC. The selection must align with the IC requirements listed to be considered responsive to that NOFO. 

Non-responsive applications will be withdrawn from consideration for this initiative. Applicants will be assigned to ICs based on usual application-IC assignment practices.

The selection must align with the NCI requirements listed below in order to be considered responsive to that NOFO.   

  • Research to increase our understanding of sex and gender differences in cancer, particularly those that occur in both women and men, including sex-stratified risks based on genomic analysis of sex chromosomes as appropriate
  • Fundamental research on gynecologic cancers that are rare, have increasing incidence, and/or documented disparities (e.g. uterine serous carcinoma), including the development of models for these cancers if none currently exist
  • Prevention, screening, and early detection research in women, including primary prevention research; research to increase education, awareness, and adherence associated with screening guidelines; and development of assays for the screening and early detection of cancers that currently lack effective screening tests (e.g. endometrial and ovarian cancers)
  • Research to understand how comorbidities, informal caregiving support, or social determinants of health, impact cancer prevention, screening, development, progression, response to treatment, and survivorship in women
  • Research to identify novel treatments for gynecological cancers that have limited treatment options and/or poor survival rates
  • Research to increase our understanding of the influence of intersectionality (acknowledging that individuals have multiple, interconnected social identities [e.g., gender, race/ethnicity, class, age, sexual orientation, disability, etc.], and these identities intersect to shape their unique experiences and positions within society) in the context of prevention, screening, care, treatment, and survivorship of individuals with cancer
  • Research to understand how the physiologic effects of menopause (including peri- and post-menopause) and subsequent treatment of menopause symptoms influence susceptibility to cancer risk

 

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