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National Cancer Institute Resources & Collaborative Programs

NCI Experimental Therapeutics Program (NExT), provides access to anticancer drug discovery and development resources to help advance projects from initial discovery to proof-of-concept clinical trials.

NCI PREVENT Programenables the progression of novel cancer preventing interventions and biomarkers through preclinical development and towards clinical trials.


NCI Funding Opportunities in Precision Medicine Oncology

The NCI's Division of Cancer Treatment & Diagnosis (DCTD) offers funding oppotunities in precision medicine oncology. Check the DCTD Funding Opportunities Page for a list of funding opportunities, announcements, and expiration date. 


Developmental Therapeutics Program (DTP) Open Chemical Repository Collection

The NCI DTP Open Chemical Repository Collection maintains a repository of synthetic compounds and pure natural products that are available to investigators for non-clinical research purposes. Over 20,000 vialed samples and 3,500 plates are shipped from the Repository to external investigators throughout the world annually. Repository collection is a uniquely diverse set of more than 200,000 compounds that have been either submitted to DTP for biological evaluation or, in some cases, synthesized under DTP auspices. 

Importantly, investigators should note that chemical structures of these substances are those assigned by the originator of the material and in the vast majority of cases, the compounds have not been analyzed by DTP for accuracy of structure or for the purity of the sample. Compounds are available through a web-based ordering system.

See the DTP Open Chemical Repository for more information about the including ordering procedures. 

NCI Cancer Diagnosis Program (CDP): Human Biospecimen Resources

  • The Cooperative Human Tissue Network (CHTN) prospectively collects and provides human tissue specimens (malignant, benign, diseased and normal tissues) and pathology report data for use in basic discovery and translational cancer research. The procurement and processing of specimens varies according to the protocol of each individual investigator: fresh, frozen, or chemically-fixed. The CHTN also produces tissue microarrays from multiple tissue types to study cancer and other diseases. Isolation and distribution of the nucleic acids from the CHTN-procured specimens can also be performed to serve the investigator’s interest.

  • Cancer Diagnosis Program (CDP) Tissue Microarrays (TMAs)

    • Breast Cancer Progression and Prognostic TMAs were constructed using tissue and associated pathological and clinical outcome data from the Cooperative Breast Cancer Tissue Resource (CBCTR). The CDP Progression TMA is designed to permit comparisons of biomarker expression across three stages of disease (node-negative, node positive and metastatic). The CDP Prognostic TMA is designed for examination of biomarkers and correlation with survival and recurrence outcomes in stage I, II and III breast cancer. Both TMAs were designed to ensure high statistical power for evaluation and validation of breast cancer biomarkers.

    • Melanoma Progression TMA consists of 273 tissue specimens containing nevi, primary melanomas, metastatic melanoma to the lymph node, and visceral and dermal metastatic melanoma. This TMA is designed to investigate differences in expression of markers in various stages of melanoma progression and should be used as a screening array.

    • Colon Cancer Progression-Prognostic TMA has over 350 primary colon cancers and 100 control tissues and is designed for examination of associations of markers with tumor stage, clinical outcome, and other clinico-pathological variables in Stage I-IV colon cancer.

  • The NCI Specimen Resource Locator is a searchable database that helps researchers locate specimens for research. The database includes resources such as tissue banks and tissue procurement services with access to normal, benign, pre-cancerous and/or cancerous human tissue. The NCI Cooperative Group Banks associated with large Phase II and Phase III clinical trials have banked tumor specimens from large numbers of uniformly treated cancer patients with a variety of malignancies. Each group (ACOSOG, CALGB, COG, ECOG, GOG, NCCTG, NCIC-CTG, NSABP, RTOG, and SWOG) has a review process for research proposals. If proposals receive favorable reviews, specimens with clinical, treatment, and outcome data can be made available to researchers through collaborative arrangements. These well annotated specimens are most useful for clinical correlative studies in randomized uniformly treated patient populations. To access these specimens, interested investigators may visit the NCI Specimen Resource Locator Website or contact the NCI Tissue Expediter at

NCI Cancer Imagine Program: The Cancer Imaging Archive (TCIA)

The NCI Cancer Imaging Program supports two archives of medical images of cancer accessible for public download. All images contained in the archives are stored in DICOM file format.

  • The National Biomedical Imaging Archive (NBIA). The NBIA contains two CT Colonography collections and multiple collections from the Reference Image Database to Evaluate Therapy Response (RIDER).
  • The Cancer Imaging Archive.  The TCIA contains the Lung Image Database Consortium image collection and a growing set of image collections linked to cases analyzed by The Cancer Genome Atlas, among others. 

Frederick National Laboratory for Cancer Research (FNLCR), offers partnering opportunities providing a wide range of advanced technologies and platforms, including cancer model development, genetics & genomics, proteins & proteomics, clinical assay development, nanotechnology characterization, high-performance biomedical computing, and advanced biomedical imaging.

Additional National Institutes of Health Resources & Programs

See the workshop page for the  Federal Resources to Accelerate Commercialization to download presentations from the programs below.


Federal Funding Opportunities for Cancer Technology 

See the workshop on Federal Resources to Accelerate Commercialization to download presentations from the federal agencies below. 

Federal Resources and Programs for Small Businesses 

See the workshop on Federal Resources to Accelerate Commercialization to download presentations from the federal agencies below.

U.S. Small Business Administration Affordable Care Act Resources

The Affordable Care Act (ACA) includes a variety of measures specifically for small businesses. Learn about the key provisions of ACA with the following resources from the U.S. Small Business Administration (SBA).

Updated Date: 
January 24, 2018