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This page is includes guidance and active notices relevant to NCI SBIR and STTR applicants. Please visit this page often to view new opportunities. You may also sign up to receive email updates from the NCI SBIR & STTR Program announcing new notices and funding opportunities. If you would like to receive updates from the NCI SBIR and STTR Program, please click here and provide the requested information.

Relevant Notices

  • NOT-OD-17-008 - Request for Information (RFI): Research supplement to promote workforce diversity in small business.

  • NOT-OD-17-005 - Optional electronic submission method to request to submit an unsolicited application that will exceed $500,000 in direct costs.

  • NOT-OD-17-001 - NIH operates under continuing resolution.

  • NOT-OD-17-006 - Request for Information (RFI): Including preprints and interim research products in NIH applications and reports.

  • NOT-OD-16-129 - New policy eliminates most appendix material for NIH/AHRQ/NIOSH applications submitted for due dates on or after January 25, 2017 (THIS NOTICE DOES NOT APPLY TO THE JANUARY 5, 2017 OR JANUARY 9, 2017 DEADLINE.)

  • NOT-OD-16-130 - Changes to the NIH/AHRQ Policy on Post-submission materials for applications submitted for due dates on or after January 25, 2017 (THIS NOTICE DOES NOT APPLY TO THE JANUARY 5, 2017 OR JANUARY 9, 2017 DEADLINE.)

  • NOT-OD-16-103The 2016 Omnibus Grant Funding Opportunity Announcements (FOAs) of the NIH, CDC, FDA and ACF are now available for the SBIR and STTR (NIH only) programs.

  • NOT-OD-16-052The NIH Direct-to-Phase II program will accept Phase II submissions regardless of the funding source for the Phase I-like proof of principle work on which the proposed Phase II research is based.

  • NOT-OD-15-156 - Small businesses may now use the ASSIST program to submit SBIR and STTR grant applications.

  • Grants Policy Statements - Effective for all NIH grants and cooperative agreements with budget periods beginning on or after December 26, 2014 and awards receiving supplemental funds on or after that date. This is also the policy source for terms and conditions NIH awards made to domestic and foreign organizations.

  • Simplifying the NIH Policy for Late Application Submission

  • HHS Changes Standard Due Dates for SBIR/STTR Grant Applications

  • NOT-OD-13-109: Niche Program. The Niche Assessment Program provides market insight and data that can be used to help small businesses strategically position their technology in the marketplace.

  • NOT-OD-14-110Commercialization Assistance Program (CAP). The CAP is specifically designed to assist NIH SBIR Phase II grantees through training workshops, individual mentoring, and consulting sessions. 

  • NOT-OD-14-074: NIH Policy on Resubmission Applications

  • NOT-OD-14-048: NIH Implements Option for Applicants to Switch between the SBIR/STTR programs and the SBIR Direct to Phase II pilot of the SBIR/STTR Reauthorization Act of 2011 


Other Guidance Resources

Animal Welfare Guidance

Genome Data Sharing

Human Subject Related Guidance

Inclusion Guidance

Resource Sharing

Additional Grants Policy & Guidance for applicants may be found at

Updated: October 24, 2016